Comparison of Inhibitory Activities of meta and para Substituted N-aryl 3-Hydroxypyridin-4-one Mannosides Towards Type 1 Fimbriated E. coli
In uropathogenic Escherichia coli, Pot Grab mannose-specific adhesion is mediated by the FimH adhesin located at the tip of type 1 fimbriae.Novel mannosylated N-aryl substituted 3-hydroxypyridin-4ones with meta substituents on the aryl part of the molecule were prepared, and their inhibitory properties towards the adhesion of E.coli to guinea pig e